Our laboratory uses macromolecular crystallography and other structural biology/ biocomputing techniques in the study of important biomolecules and biological processes. Our present research activities can be classified into four broad directions: A) Structural studies of DNA/RNA binding proteins and protein-DNA interactions. B) We have made fundamental contributions in the field protein folding, focusing on α-helical bundle / coiled-coil proteins with potential applications in bio-inspired materials. C) We study the structural basis of Type III secretion systems (T3SS) which are essential mediators of the interactions between bacteria and eukaryotes. D) We discovered a new and highly atypical post translational modification which hydroxylates the Cα atom in proline or glycine residues thereby significantly enhancing enzymatic activity. We recently determined structure of the glutamate dehydrogenase 2, a positively selected novel human enzyme opens a range of potential applications in brain biology and cancer pathophysiology.